In 1899, Ernest Rutherford discovered that uranium radiation is composed of positively charged alpha particles and negatively charged beta particles.
In 1913, Niels Bohr identified radioactivity as a specific property of the nucleus of the atom, rather than being a general property of the atom as a whole.
In 1917, Ernest Rutherford and Marsden described artificial transmutation of elements, after having produced hydrogen and oxygen from nitrogen.
In 1929, John Cockcroft and Ernest Walton succeeded in 'atom-smashing' as it was called, using equipment based on four glass cylinders taken from petrol pumps.
In 1932, John Cockcroft and Ernest Walton took linear proton accelerators to an energy of 700 keV and verified the mass/energy equivalence.
Cockcroft and Walton used accelerated protons, hydrogen ions to split lithium and boron nuclei, and also to make unstable nuclei that were radioactive.
In 1934, Irène Joliot-Curie and Frédéric Joliot-Curie bombarded aluminium atoms with alpha particles to create artificially radioactive phosphorus-30.